PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo

PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo

Abstract Background Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tumor progression, however, the role of PAK5 in breast cancer remains...

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Bibliographic Details
Main Authors: Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou, Dong-Sheng Pei
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PAK5
p65
Cyclin D1
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s13046-017-0610-5

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http://link.springer.com/article/10.1186/s13046-017-0610-5

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