High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to regulation of the cyclooxygenase (COX) enzymes have...

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Bibliographic Details
Main Authors: Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J Maloney, Ewa S Pilka, Minghua Wang, Udo Oppermann, Tom D Heightman, Anton Simeonov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2970562?pdf=render

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http://europepmc.org/articles/PMC2970562?pdf=render

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