Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were...

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Bibliographic Details
Main Authors: Matthias Richard, Ana Victoria Gutiérrez, Albertus J. Viljoen, Eric Ghigo, Mickael Blaise, Laurent Kremer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium abscessus
TetR regulator
MmpL
efflux pump
structure
thiacetazone analogs
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00649/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00649/full

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