Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

Abstract Background Medulloblastoma (MB) is the most common malignant brain tumour in children but also rarely occur in adults. Sonic Hedgehog (SHH) driven MB is associated with aberrant activation of the SHH signalling pathway. SMO inhibitors, sonidegib and vismodegib, have been used as selective a...

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Bibliographic Details
Main Authors: Yuchen Li, Qingkun Song, Bryan W. Day
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
Medulloblastoma
Sonic hedgehog pathway
SMO inhibitor
Sonidegib
And vismodegib
Online Access:http://link.springer.com/article/10.1186/s40478-019-0773-8

Internet

http://link.springer.com/article/10.1186/s40478-019-0773-8

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