A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

Natural antioxidants represented by quercetin have been documented to be effective against atherosclerosis. However, the related mechanisms remain largely unclear. In this study, we identified a novel anti-atherosclerotic mechanism of quercetin inhibiting macrophage pyroptosis by activating NRF2 thr...

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Bibliographic Details
Main Authors: Xing Luo, Xiuzhu Weng, Xiaoyi Bao, Xiaoxuan Bai, Ying Lv, Shan Zhang, Yuwu Chen, Chen Zhao, Ming Zeng, Jianxin Huang, Biyi Xu, Thomas W. Johnson, Stephen J. White, Ji Li, Haibo Jia, Bo Yu
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Atherosclerosis
Quercetin
Pyroptosis
Oxidative stress
KEAP1/NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200283X

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http://www.sciencedirect.com/science/article/pii/S221323172200283X

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