Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

Aim: Evaluate the influence of doxycycline, an anti-inflammatory and matrix metalloproteinase (MMP) inhibitor, on the attenuation of chronic doxorubicin-induced cardiotoxicity in rats. Methods: We allocated male Wistar rats into four groups: control (C), doxorubicin (D), doxycycline (inhibitor of MM...

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Bibliographic Details
Main Authors: Danielle Dantas, Amanda Gomes Pereira, Anderson Seiji Soares Fujimori, Ana Paula Dantas Ribeiro, Carol Cristina Vágula de Almeida Silva, Marina Gaiato Monte, Camila Renata Corrêa, Ana Angélica Fernandes, Silmeia Garcia Zanati Bazan, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Sergio Alberto Rupp de Paiva, Leonardo Antônio Mamede Zornoff, Bertha Furlan Polegato
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
doxycycline
myocardial energy metabolism
oxidative stress
MMP-2
collagen I
TIMP-4
Online Access:https://www.mdpi.com/2308-3425/9/8/254

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https://www.mdpi.com/2308-3425/9/8/254

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