Nanoparticle‐Mediated Simultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates Myocardial Ischemia‐Reperfusion Injury

Nanoparticle‐Mediated Simultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates Myocardial Ischemia‐Reperfusion Injury

Background The opening of mitochondrial permeability transition pore and inflammation cooperatively progress myocardial ischemia‐reperfusion (IR) injury, which hampers therapeutic effects of primary reperfusion therapy for acute myocardial infarction. We examined the therapeutic effects of nanoparti...

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Bibliographic Details
Main Authors: Gentaro Ikeda, Tetsuya Matoba, Ayako Ishikita, Kazuhiro Nagaoka, Kaku Nakano, Jun‐ichiro Koga, Hiroyuki Tsutsui, Kensuke Egashira
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardioprotection
drug delivery system
ischemia‐reperfusion injury
nanotechnology
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.019521

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.019521

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