Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent

The hepatic uridine 5′-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can regulate hepatic UGT expression and differential...

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Bibliographic Details
Main Authors: Steffen G. Oeser, Jon-Paul Bingham, Abby C. Collier
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/10/1/6