Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer

Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer

BackgroundCombination therapy with immune checkpoint inhibitors (ICIs) may benefit approximately 10-20% of microsatellite-stable colorectal cancer (MSS-CRC) patients. However, there is a lack of optimal biomarkers. This study aims to understand the predictive value of epigenetic-related gene mutatio...

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Bibliographic Details
Main Authors: Chao Liu, Huiting Xiao, Luying Cui, Lin Fang, Shuling Han, Yuli Ruan, Wenyuan Zhao, Yanqiao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitor therapy
biomarker
microsatellite-stable
colorectal cancer
epigenetic-related gene mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039631/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039631/full

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