Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease
Abstract Background A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and parietal hypometabolism, lower cerebrospinal fluid amyloid β 1–42, and in...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13195-019-0471-6 |
| _version_ | 1819049593819627520 |
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| author | Omar A. Halawa Jennifer R. Gatchel Rebecca E. Amariglio Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Gad A. Marshall Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Omar A. Halawa Jennifer R. Gatchel Rebecca E. Amariglio Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Gad A. Marshall Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Omar A. Halawa |
| collection | DOAJ |
| description | Abstract Background A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and parietal hypometabolism, lower cerebrospinal fluid amyloid β 1–42, and inferior temporal cortical thinning. Identifying the underlying biomarkers of functional decline will allow for the early identification of individuals at risk of disease progression. Objective To investigate the association between IADL impairment and in vivo regional cerebral tau and cortical amyloid deposition across clinically normal (CN) elderly, MCI, and AD dementia. Methods Fifty-one CN elderly, 30 MCI, and 9 AD dementia participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) underwent assessment of regional tau deposition with flortaucipir (FTP) positron emission tomography (PET). An aggregate of cortical amyloid burden was assessed by florbetapir PET. IADL were assessed using the Functional Activities Questionnaire (FAQ). Tau regions with unadjusted correlations of p ≤ 0.006 (Bonferroni correction) with FAQ were used to evaluate the cross-sectional association between FAQ (dependent variable) and regional cerebral tau deposition, amyloid burden, and tau-amyloid interaction in separate general linear regression models with backward elimination. Covariates included age, American National Adult Reading Test (AMNART) intelligence quotient (IQ), and Rey Auditory Verbal Learning Test (RAVLT) total learning. Results Unadjusted correlations between FAQ and tau in the entorhinal cortex (EC) and inferior temporal cortex (IT) survived Bonferroni correction. FAQ was associated with the tau-amyloid interaction, such that in participants with greater amyloid burden, greater IADL impairment was associated with greater regional tau (EC tau × amyloid: partial r (pr) = 0.47, p < 0.001; IT tau × amyloid: pr = 0.54, p < 0.001). Significant associations were found when these regression models were repeated in symptomatic participants alone but not among CN participants. Conclusions Greater medial and inferior temporal tau and cortical amyloid burden were associated with greater IADL impairment in AD. Further elucidation of the biomarkers underlying the functional decline will allow for the early identification of individual at risk of disease progression. |
| first_indexed | 2024-12-21T11:34:37Z |
| format | Article |
| id | doaj.art-da2f5f332b5f40e2807129c5f078e232 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-21T11:34:37Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-da2f5f332b5f40e2807129c5f078e2322022-12-21T19:05:28ZengBMCAlzheimer’s Research & Therapy1758-91932019-01-0111111010.1186/s13195-019-0471-6Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s diseaseOmar A. Halawa0Jennifer R. Gatchel1Rebecca E. Amariglio2Dorene M. Rentz3Reisa A. Sperling4Keith A. Johnson5Gad A. Marshall6Alzheimer’s Disease Neuroimaging InitiativeHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolAbstract Background A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and parietal hypometabolism, lower cerebrospinal fluid amyloid β 1–42, and inferior temporal cortical thinning. Identifying the underlying biomarkers of functional decline will allow for the early identification of individuals at risk of disease progression. Objective To investigate the association between IADL impairment and in vivo regional cerebral tau and cortical amyloid deposition across clinically normal (CN) elderly, MCI, and AD dementia. Methods Fifty-one CN elderly, 30 MCI, and 9 AD dementia participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) underwent assessment of regional tau deposition with flortaucipir (FTP) positron emission tomography (PET). An aggregate of cortical amyloid burden was assessed by florbetapir PET. IADL were assessed using the Functional Activities Questionnaire (FAQ). Tau regions with unadjusted correlations of p ≤ 0.006 (Bonferroni correction) with FAQ were used to evaluate the cross-sectional association between FAQ (dependent variable) and regional cerebral tau deposition, amyloid burden, and tau-amyloid interaction in separate general linear regression models with backward elimination. Covariates included age, American National Adult Reading Test (AMNART) intelligence quotient (IQ), and Rey Auditory Verbal Learning Test (RAVLT) total learning. Results Unadjusted correlations between FAQ and tau in the entorhinal cortex (EC) and inferior temporal cortex (IT) survived Bonferroni correction. FAQ was associated with the tau-amyloid interaction, such that in participants with greater amyloid burden, greater IADL impairment was associated with greater regional tau (EC tau × amyloid: partial r (pr) = 0.47, p < 0.001; IT tau × amyloid: pr = 0.54, p < 0.001). Significant associations were found when these regression models were repeated in symptomatic participants alone but not among CN participants. Conclusions Greater medial and inferior temporal tau and cortical amyloid burden were associated with greater IADL impairment in AD. Further elucidation of the biomarkers underlying the functional decline will allow for the early identification of individual at risk of disease progression.http://link.springer.com/article/10.1186/s13195-019-0471-6Alzheimer’s diseaseInstrumental activities of daily livingTauAmyloidPositron emission tomographyMild cognitive impairment |
| spellingShingle | Omar A. Halawa Jennifer R. Gatchel Rebecca E. Amariglio Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Gad A. Marshall Alzheimer’s Disease Neuroimaging Initiative Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease Alzheimer’s Research & Therapy Alzheimer’s disease Instrumental activities of daily living Tau Amyloid Positron emission tomography Mild cognitive impairment |
| title | Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease |
| title_full | Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease |
| title_fullStr | Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease |
| title_full_unstemmed | Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease |
| title_short | Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease |
| title_sort | inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in alzheimer s disease |
| topic | Alzheimer’s disease Instrumental activities of daily living Tau Amyloid Positron emission tomography Mild cognitive impairment |
| url | http://link.springer.com/article/10.1186/s13195-019-0471-6 |
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