Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Thyroid hormones have an important role in fostering tumour progression, however their upstream regulators are less clear. Here, the authors identify the thyroid hormone activating enzyme type 2 deiodinase as a p53 target gene and demonstrate its contribution to tumour progression in p53 mutant squa...

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Bibliographic Details
Main Authors: Annarita Nappi, Caterina Miro, Antonio Pezone, Alfonso Tramontano, Emery Di Cicco, Serena Sagliocchi, Annunziata Gaetana Cicatiello, Melania Murolo, Sepehr Torabinejad, Elena Abbotto, Giuseppina Caiazzo, Maddalena Raia, Mariano Stornaiuolo, Dario Antonini, Gabriella Fabbrocini, Domenico Salvatore, Vittorio Enrico Avvedimento, Monica Dentice
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36755-y

Internet

https://doi.org/10.1038/s41467-023-36755-y

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