Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system

Abstract Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the lipid-lowering and cardioprotective properties of bilirubin, as well as the negative relationship between bilirubin and atherosclerosis, were well d...

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Bibliographic Details
Main Authors: Guanmei Wen, Leyi Yao, Yali Hao, Jinheng Wang, Jinbao Liu
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-021-03207-4