Association of basal hyperglucagonemia with impaired glucagon counterregulation in type 1 diabetes

Association of basal hyperglucagonemia with impaired glucagon counterregulation in type 1 diabetes

Glucagon Counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (Ba...

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Bibliographic Details
Main Authors: Leon S Farhy, Alice eChan, Marc D Breton, Stacey M Anderson, Boris P Kovatchev, Anthony L McCall
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Physiology
Subjects:
Diabetes Mellitus
Feedback
Hypoglycemia
mathematical model
glucagon counterregulation
hyperglucagonemia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00040/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00040/full

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