Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to...

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Bibliographic Details
Main Authors: Nancy Nader, Maya Dib, Rawad Hodeify, Raphael Courjaret, Asha Elmi, Ayat S Hammad, Raja Dey, Xin-Yun Huang, Khaled Machaca
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000901

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https://doi.org/10.1371/journal.pbio.3000901

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