Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhibitors specific for each BCL2 pro-survival protein....

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Bibliographic Details
Main Authors: Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
computational protein design
cancer
Bcl-2
Online Access:https://elifesciences.org/articles/20352

Internet

https://elifesciences.org/articles/20352

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