Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identificat...

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Bibliographic Details
Main Authors: James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
glioblastoma
astrocytes
DNA methylation
Online Access:https://elifesciences.org/articles/77335

Internet

https://elifesciences.org/articles/77335

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