An Engineered Endomorphin-2 Gene for Morphine Withdrawal Syndrome.

An optimal therapeutics to manage opioid withdrawal syndrome is desired for opioid addiction treatment. Down-regulation of endogenous endomorphin-2 (EM2) level in the central nervous system after continuous morphine exposure was observed, which suggested that increase of EM2 could be an alternative...

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Bibliographic Details
Main Authors: Fei-Xiang Wu, Yan He, Hui-Ting Di, Yu-Ming Sun, Rui-Rui Pan, Wei-Feng Yu, Renyu Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4803333?pdf=render