Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect

Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect

Abstract Background To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe a method, applicable to a broad range of association study designs, that can simulate autosome-wide single-nucleotide polymorphism data with re...

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Bibliographic Details
Main Authors: M. Shi, D. M. Umbach, A. S. Wise, C. R. Weinberg
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Bioinformatics
Subjects:
Genotype simulation
Genome-wide association
Case-parent triads
Linkage disequilibrium
Epistasis
Online Access:http://link.springer.com/article/10.1186/s12859-017-2004-2

Internet

http://link.springer.com/article/10.1186/s12859-017-2004-2

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