Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties...

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Bibliographic Details
Main Authors: Alejandro Gonzalez-Candia, Marcelino Veliz, Catalina Carrasco-Pozo, Rodrigo L. Castillo, J. Cesar Cárdenas, Germán Ebensperger, Roberto V. Reyes, Aníbal J. Llanos, Emilio A. Herrera
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718308978