Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy

Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy

Paclitaxel (PTX)-induced peripheral neuropathy (PIPN) induces numerous symptoms affecting patient quality of life, leading to decreased doses or even to cessation of anticancer therapy. Previous studies have reported that a widely used drug, ramipril, improves neuroprotection in several rodent model...

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Bibliographic Details
Main Authors: Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
paclitaxel-induced peripheral neuropathy
angiotensin converting enzyme inhibitor
Ramipril
neuropathic pain
mouse model
Online Access:https://www.mdpi.com/1999-4923/14/4/848

Internet

https://www.mdpi.com/1999-4923/14/4/848

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