Pancreatic cancer‐derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP‐1 signaling pathways

Pancreatic cancer‐derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP‐1 signaling pathways

Cancer‐associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor‐derived small extracellular vesicles (sEVs), which mediate cell‐to‐cell communicatio...

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Bibliographic Details
Main Authors: Yu‐Ting Chang, Hsuan‐Yu Peng, Chun‐Mei Hu, Sui‐Chih Tien, Yi‐Ing Chen, Yung‐Ming Jeng, Ming‐Chu Chang
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Molecular Oncology
Subjects:
cancer‐associated fibroblasts
ezrin
metastasis
pancreatic ductal adenocarcinoma
small extracellular vesicles
Online Access:https://doi.org/10.1002/1878-0261.13442

Internet

https://doi.org/10.1002/1878-0261.13442

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