Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas<sup>lpr</sup> Mice

Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas<sup>lpr</sup> Mice

KH-type splicing regulatory protein (KSRP) is an RNA-binding protein that promotes mRNA decay and thereby negatively regulates cytokine expression at the post-transcriptional level. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated cytokine expression causing...

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Bibliographic Details
Main Authors: Lisa Schmidtke, Myriam Meineck, Sabrina Saurin, Svenja Otten, Fabian Gather, Katharina Schrick, Rudolf Käfer, Wilfried Roth, Hartmut Kleinert, Julia Weinmann-Menke, Andrea Pautz
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
systemic lupus erythematosus
glomerulonephritis
post-transcriptional regulation
cytokine
KSRP
Online Access:https://www.mdpi.com/2073-4409/10/11/3167

Internet

https://www.mdpi.com/2073-4409/10/11/3167

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