A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary cerebral small vessel disease (SVD), currently lacks disease-modifying treatments. Adrenomedullin (AM), a vasoactive peptide with angiogenic, vasodilat...

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Bibliographic Details
Main Authors: Kazuo Washida, Satoshi Saito, Tomotaka Tanaka, Yuriko Nakaoku, Hiroyuki Ishiyama, Soichiro Abe, Takehito Kuroda, Shinsaku Nakazawa, Chikage Kakuta, Katsuhiro Omae, Kenta Tanaka, Manabu Minami, Yoshiaki Morita, Tetsuya Fukuda, Akihiro Shindo, Takakuni Maki, Kazuo Kitamura, Hidekazu Tomimoto, Toshihiko Aso, Masafumi Ihara
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cerebral Circulation - Cognition and Behavior
Subjects:
Adrenomedullin
Arterial spin labeling
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Cerebral blood flow
Clinical trial
Online Access:http://www.sciencedirect.com/science/article/pii/S2666245024000126

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http://www.sciencedirect.com/science/article/pii/S2666245024000126

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