Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

Aquaporin-0 (AQP0) tetramers form square arrays in lens membranes through a yet unknown mechanism, but lens membranes are enriched in sphingomyelin and cholesterol. Here, we determined electron crystallographic structures of AQP0 in sphingomyelin/cholesterol membranes and performed molecular dynamic...

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Bibliographic Details
Main Authors: Po-Lin Chiu, Juan D Orjuela, Bert L de Groot, Camilo Aponte Santamaría, Thomas Walz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-09-01
Series:eLife
Subjects:
electron crystallography
molecular dynamics simulations
lipid rafts
cholesterol
array formation
Online Access:https://elifesciences.org/articles/90851

Internet

https://elifesciences.org/articles/90851

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