Overproduction of clavulanic acid by extractive fermentation

Overproduction of clavulanic acid by extractive fermentation

Background: Clavulanic acid is an important beta-lactamase inhibitor produced as a secondary metabolite by the actinomycete Streptomyces clavuligerus. Clavulanic acid is chemically unstable; therefore, it is degraded during bacterial cultivation. In this work, the adsorbents clinoptilolite, activate...

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Bibliographic Details
Main Authors: Cecília Ladeira Lopes Costa, Alberto Colli Badino
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Electronic Journal of Biotechnology
Subjects:
Adsorption
Clavulanic acid
Extractive fermentation
Integrated processing
Product inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345815000378

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http://www.sciencedirect.com/science/article/pii/S0717345815000378

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