Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer’s Disease Patients

Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer’s Disease Patients

Background: Bisdemethoxycurcumin (BDC) might be an inflammation inhibitor in Alzheimer’s Disease (AD). However, BDC is almost insoluble in water, poorly absorbed by the organism, and degrades rapidly. We thus developed a new nanoformulation of BDC based on H-Ferritin nanocages (BDC-HFn). Methods: We...

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Bibliographic Details
Main Authors: Stella Gagliardi, Marta Truffi, Veronica Tinelli, Maria Garofalo, Cecilia Pandini, Matteo Cotta Ramusino, Giulia Perini, Alfredo Costa, Sara Negri, Serena Mazzucchelli, Arianna Bonizzi, Leopoldo Sitia, Maria Busacca, Marta Sevieri, Michela Mocchi, Alessandra Ricciardi, Davide Prosperi, Fabio Corsi, Cristina Cereda, Carlo Morasso
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
bisdemethoxycurcumin
H-Ferritin
Alzheimer’s disease
gene expression
inflammation
curcumin
Online Access:https://www.mdpi.com/1422-0067/23/16/9237

Internet

https://www.mdpi.com/1422-0067/23/16/9237

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