The bioactive peptide VLATSGPG regulates the abnormal lipid accumulation and inflammation induced by free fatty acids in HepG2 cells via the PERK signaling pathway

The bioactive peptide VLATSGPG regulates the abnormal lipid accumulation and inflammation induced by free fatty acids in HepG2 cells via the PERK signaling pathway

VLATSGPG (VLA) was a DPP-IV inhibitory peptide isolated from salmon (Salmo Salar) skin. Here, we demonstrated that VLA inhibited the activation of PERK through the AKT signaling pathway. Furthermore, we investigated the effect of VLA on free fatty acid (FFA)-induced lipid accumulation disorder and i...

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Bibliographic Details
Main Authors: Ritian Jin, Jude Juventus Aweya, Rong Lin, Wuyin Weng, Jiaqi Shang, Dangfeng Wang, Yiling Fan, Shen Yang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Functional Foods
Subjects:
DPP-IV inhibitory peptide
Free fatty acids
NAFLD
PERK
HepG2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623001159

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http://www.sciencedirect.com/science/article/pii/S1756464623001159

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