Self-Adjuvanting Calcium-Phosphate-Coated Microcrystal-Based Vaccines Induce Pyroptosis in Human and Livestock Immune Cells

Successful vaccines require adjuvants able to activate the innate immune system, eliciting antigen-specific immune responses and B-cell-mediated antibody production. However, unwanted secondary effects and the lack of effectiveness of traditional adjuvants has prompted investigation into novel adjuv...

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Bibliographic Details
Main Authors: Yolanda Corripio-Miyar, Clair Lyle MacLeod, Iris Mair, Richard J. Mellanby, Barry D. Moore, Tom N. McNeilly
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/11/7/1229