Iridium-catalyzed direct asymmetric reductive amination utilizing primary alkyl amines as the N-sources
Direct asymmetric reductive amination is one of the most efficient methods for obtaining chiral amines. Here the authors show how primary alkyl amines can undergo this transformation in the presence of an iridium catalyst with sterically tuneable chiral phosphoramidite ligands, achieving the synthes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31045-5 |