Establishment of rat embryonic stem cells and making of chimera rats.

The rat is a reference animal model for physiological studies and for the analysis of multigenic human diseases such as hypertension, diabetes, neurological disorders, and cancer. The rats have long been used in extensive chemical carcinogenesis studies. Thus, the rat embryonic stem (rES) cell is an...

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Bibliographic Details
Main Authors: Shinobu Ueda, Masaki Kawamata, Takumi Teratani, Taku Shimizu, Yoshitaka Tamai, Hiromasa Ogawa, Katsuyuki Hayashi, Hiroyuki Tsuda, Takahiro Ochiya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2483735?pdf=render