The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix

The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix

Usual interstitial pneumonia (UIP) is a histological pattern characteristic of idiopathic pulmonary fibrosis (IPF). The UIP pattern is patchy with histologically normal lung adjacent to dense fibrotic tissue. At this interface, fibroblastic foci (FF) are present and are sites where myofibroblasts an...

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Bibliographic Details
Main Authors: Jeremy A. Herrera, Lewis Dingle, M. Angeles Montero, Rajamiyer V. Venkateswaran, John F. Blaikley, Craig Lawless, Martin A. Schwartz
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-08-01
Series:JCI Insight
Subjects:
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.156115

Internet

https://doi.org/10.1172/jci.insight.156115

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