Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model

Abstract Coarctation of the aorta (CoA) is one of the most common congenital cardiovascular diseases. CoA patients frequently undergo surgical repair, but hypertension (HTN) is still common. The current treatment guideline has revealed irreversible changes in structure and function, yet revised seve...

Full description

Bibliographic Details
Main Authors: Jamasp Azarnoosh, Arash Ghorbannia, El-Sayed H. Ibrahim, Hilda Jurkiewicz, Lindsey Kalvin, John F. LaDisa
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34400-8