In vitro and in vivo Repair Effects of the NCF-Col-NHA Aerogel Scaffold Loaded With SOST Monoclonal Antibody and SDF-1 in Steroid-Induced Osteonecrosis

In vitro and in vivo Repair Effects of the NCF-Col-NHA Aerogel Scaffold Loaded With SOST Monoclonal Antibody and SDF-1 in Steroid-Induced Osteonecrosis

In the current study, we synthesized nanocellulose (NCF)-collagen (Col)-nano hydroxyapatite (NHA) organic-inorganic hybrid aerogels loaded with stromal cell derived factor-1 (SDF-1) and sclerostin monoclonal antibody (SOST McAb) and investigated their ability to repair steroid-induced osteonecrosis....

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Bibliographic Details
Main Authors: Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
aerogel
steroid-induced osteonecrosis
bone repair
sost
bone regenaration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.825231/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.825231/full

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