Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules

Abstract Imeglimin is a new anti-diabetic drug commercialized in Japan (Twymeeg®) and has been drawing much attention in diabetes research area as well as in clinical practice. In this study, we evaluated the effect of imeglimin on pancreatic β-cells. First, single-dose administration of imeglimin e...

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Bibliographic Details
Main Authors: Junpei Sanada, Atsushi Obata, Yoshiro Fushimi, Tomohiko Kimura, Masashi Shimoda, Tomoko Ikeda, Yuka Nogami, Yoshiyuki Obata, Yuki Yamasaki, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17657-3

Internet

https://doi.org/10.1038/s41598-022-17657-3

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