Non-Inflamed Tumor Microenvironment and Methylation/Downregulation of Antigen-Presenting Machineries in Cholangiocarcinoma

Non-Inflamed Tumor Microenvironment and Methylation/Downregulation of Antigen-Presenting Machineries in Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a refractory cancer; a majority of CCAs represents a non-inflamed tumor phenotype that should be resistant to treatment, including immune checkpoint inhibitors (ICIs). In this study, we aimed to understand the molecular characteristics associated with non-inflamed CCAs. T...

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Bibliographic Details
Main Authors: Naoshi Nishida, Tomoko Aoki, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Hiroshi Ida, Satoru Hagiwara, Yasunori Minami, Kazuomi Ueshima, Masatoshi Kudo
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
cholangiocarcinoma
tumor microenvironment
methylation
downregulation
antigen-presenting machinery
human leukocyte antigen
Online Access:https://www.mdpi.com/2072-6694/15/8/2379

Internet

https://www.mdpi.com/2072-6694/15/8/2379

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