ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension

ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension

BackgroundPulmonary hypertension (PH), characterized by elevated pulmonary pressure and right heart failure, is a systemic disease involving inappropriate sympathetic activation and an impaired gut-brain-lung axis. Global overexpression of angiotensin converting enzyme 2 (ACE2), a cardiopulmonary pr...

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Bibliographic Details
Main Authors: Aline C. Oliveira, Marianthi M. Karas, Matthew Alves, Jacky He, Annette D. de Kloet, Eric G. Krause, Elaine M. Richards, Andrew J. Bryant, Mohan K. Raizada
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
pulmonary hypertension
dysautonomia
chronic hypoxia
brain-lung axis
neuroinflammation
neuroimmune interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1223733/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1223733/full

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