A Novel Single-Tube Next Generation Sequencing Assay for B-Cell Receptor Clonality Testing

A Novel Single-Tube Next Generation Sequencing Assay for B-Cell Receptor Clonality Testing

B-cell neoplasms possess clonal B-cell receptor rearrangements (BCR clonotype lineages) that can be identified by sequencing the B-cell repertoire for use in diagnostics, risk stratification, and high-sensitivity monitoring. BCR somatic hypermutation (SHM) can result in clonality detection failure f...

Full description

Bibliographic Details
Main Authors: Landon Pastushok, Shrutii Sarda, Karen Mochoruk, Wayne Hill, Loni T. Pickle, Michelle Toro, Carolina Gonzalez, Stephanie Ostresh, Timothy J. Looney, Chenchen Yang, Julie Stakiw, Mark J. Bosch, Hadi Goubran, C. Ronald Geyer, Geoffrey M. Lowman, John F. DeCoteau
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Journal of Molecular Pathology
Subjects:
B-cell neoplasia
multiple myeloma
B-cell receptor rearrangements
clonotypes
next generation sequencing
single-tube assay
Online Access:https://www.mdpi.com/2673-5261/5/1/4

Internet

https://www.mdpi.com/2673-5261/5/1/4

Similar Items