A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

BackgroundRabies is a lethal zoonotic disease that kills approximately 60,000 people each year. Although inactivated rabies vaccines are available, multiple-dose regimensare recommended for pre-exposure prophylaxis or post-exposure prophylaxis,which cuts down the cost- and time-effectiveness, especi...

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Bibliographic Details
Main Authors: Shimeng Bai, Tianhan Yang, Cuisong Zhu, Meiqi Feng, Li Zhang, Ziling Zhang, Xiang Wang, Rui Yu, Xinghao Pan, Chen Zhao, Jianqing Xu, Xiaoyan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
rabies
mRNA vaccine
rabies virus glycoprotein
virus-neutralizing antibodies
challenge model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1099991/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1099991/full

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