Analysis of glycyrrhizin binding to protein HMGB1

Glycyrrhizin (GLR) is triterpenoid saponin used for the treatment of various of liver and skin diseases. GLR blocks the nucleocytoplasmic translocation of the protein HMGB1, thereby inhibiting its extracellular release and its functions as a damage-associated molecular pattern molecule. Here we have...

Full description

Bibliographic Details
Main Authors: Gérard Vergoten, Christian Bailly
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Medicine in Drug Discovery
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098620300452