HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

Highlights • Serum biomarkers can help to distinguish benign from malignant pelvic masses • We evaluated the diagnostic value of adding HE4, CA125 and ROMA to ultrasound for detecting ovarian cancer • In stage III and IV ovarian cancer all three biomarkers showed excellent performance • ROMA and HE4...

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Bibliographic Details
Main Authors: Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen, Rudolf Tauber, Jalid Sehouli
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Cancer
Subjects:
Ovarian cancer
Endometriosis
HE4
CA125
Biomarkers
Online Access:https://doi.org/10.1186/s12885-022-09887-5

Internet

https://doi.org/10.1186/s12885-022-09887-5

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