M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop

M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop

Abstract Background Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma (OSCC). However, the functional roles a...

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Bibliographic Details
Main Authors: Yuanhe You, Zhuowei Tian, Zhong Du, Kailiu Wu, Guisong Xu, Meilu Dai, Yan’an Wang, Meng Xiao
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Macrophage
Oral squamous cell carcinoma
Epithelial-mesenchymal transfer
Cancer-stem like cells
Interleukin 6
Online Access:https://doi.org/10.1186/s13046-021-02222-z

Internet

https://doi.org/10.1186/s13046-021-02222-z

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