Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil
Six new polyene carboxylic acids named serpentemycins E–J (<b>1</b>–<b>6</b>), together with three known analogs (<b>7</b>–<b>9</b>), were isolated from the fermentation medium of <i>Streptomyces</i> sp. TB060207, which was isolated from ar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/6/2579 |
| _version_ | 1827748411878670336 |
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| author | Manyu Zhang Jinwei Ren Yuanming Luo Weidong Xie Erwei Li |
| author_facet | Manyu Zhang Jinwei Ren Yuanming Luo Weidong Xie Erwei Li |
| author_sort | Manyu Zhang |
| collection | DOAJ |
| description | Six new polyene carboxylic acids named serpentemycins E–J (<b>1</b>–<b>6</b>), together with three known analogs (<b>7</b>–<b>9</b>), were isolated from the fermentation medium of <i>Streptomyces</i> sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds <b>1</b>–<b>9</b> against NO production in LPS-activated RAW264.7 cells were evaluated. Compound <b>9</b> has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 µM. |
| first_indexed | 2024-03-11T06:07:49Z |
| format | Article |
| id | doaj.art-da8c4dd77c424181bfad9760503f958e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:07:49Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-da8c4dd77c424181bfad9760503f958e2023-11-17T12:52:18ZengMDPI AGMolecules1420-30492023-03-01286257910.3390/molecules28062579Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet SoilManyu Zhang0Jinwei Ren1Yuanming Luo2Weidong Xie3Erwei Li4Marine College, Shandong University, Weihai 264209, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaInstitutional Center for Shared Technologies and Facilities, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaMarine College, Shandong University, Weihai 264209, ChinaInstitutional Center for Shared Technologies and Facilities, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaSix new polyene carboxylic acids named serpentemycins E–J (<b>1</b>–<b>6</b>), together with three known analogs (<b>7</b>–<b>9</b>), were isolated from the fermentation medium of <i>Streptomyces</i> sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds <b>1</b>–<b>9</b> against NO production in LPS-activated RAW264.7 cells were evaluated. Compound <b>9</b> has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 µM.https://www.mdpi.com/1420-3049/28/6/2579polyene carboxylic acidsecondary metabolitesbioactivityNO production |
| spellingShingle | Manyu Zhang Jinwei Ren Yuanming Luo Weidong Xie Erwei Li Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil Molecules polyene carboxylic acid secondary metabolites bioactivity NO production |
| title | Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil |
| title_full | Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil |
| title_fullStr | Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil |
| title_full_unstemmed | Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil |
| title_short | Polyene Carboxylic Acids from a <i>Streptomyces</i> sp. Isolated from Tibet Soil |
| title_sort | polyene carboxylic acids from a i streptomyces i sp isolated from tibet soil |
| topic | polyene carboxylic acid secondary metabolites bioactivity NO production |
| url | https://www.mdpi.com/1420-3049/28/6/2579 |
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