The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated secretory phenotype (SASP), which may regulate tumorigenesis....

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Bibliographic Details
Main Authors: Daria A. Bogdanova, Ekaterina D. Kolosova, Tamara V. Pukhalskaia, Ksenia A. Levchuk, Oleg N. Demidov, Ekaterina V. Belotserkovskaya
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
cancer-associated fibroblasts (CAFs)
senescence
senescence-associated secretory phenotype (SASP)
colorectal cancer
epithelial–mesenchymal transition (EMT)
interleukin-6 (IL-6)
Online Access:https://www.mdpi.com/1422-0067/25/7/4031

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https://www.mdpi.com/1422-0067/25/7/4031

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