Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve

Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve

Calcific aortic valve disease (CAVD), a degenerative disease characterized by inflammation, fibrosis and calcification, is accelerated in diabetes. Hyperglycemia contributes to this process by mechanisms that still need to be uncovered. We have recently developed a 3D model of the human aortic valve...

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Bibliographic Details
Main Authors: Letitia Ciortan, Razvan Daniel Macarie, Sergiu Cecoltan, Mihaela Vadana, Monica Madalina Tucureanu, Andreea Cristina Mihaila, Ionel Droc, Elena Butoi, Ileana Manduteanu
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Polymers
Subjects:
gelatin methacrylate
3D model
human valvular endothelial cells
human valvular interstitial cells
high glucose levels
cytokines
Online Access:https://www.mdpi.com/2073-4360/12/12/2786

Internet

https://www.mdpi.com/2073-4360/12/12/2786

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