Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)

Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)

Abstract Background Persisting coma is a common complication in (neuro)intensive care in neurological disease such as acute ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage. Amantadine acts as a nicotinic receptor antagonist, dopamine receptor agonist and non-competitive N-Methyl...

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Bibliographic Details
Main Authors: Anna Hofmann, Corinna Blum, Constanze Single, Kamal Adeyemi, Patricia Schwarz, Vasileios Siokas, Tim W. Rattay, Helene A. Häberle, Reimer Riessen, Bettina Brendel, Iris Haug, Ruth Bösel, Manola Zago, Peter Martus, Ulf Ziemann, Annerose Mengel, Katharina Feil
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Neurology
Subjects:
Amantadine
Reduced consciousness
Coma
Neurointensive care
Stroke
Online Access:https://doi.org/10.1186/s12883-023-03345-w

Internet

https://doi.org/10.1186/s12883-023-03345-w

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