Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance

Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance

The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) blockade is a matter of intense debate. To elucidate the role of PD-L1 expression on tumor cells and the functional consequences of engaging PD-1 receptor on c...

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Bibliographic Details
Main Authors: Maria-Luisa del Rio, Jose-Antonio Perez-Simon, Jose-Ignacio Rodriguez-Barbosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
PD-1
CD80
PD-L1
PD-L2
NK cells
hybrid resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887348/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.887348/full

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