Endothelial Activin Receptor-Like Kinase 1 (ALK1) Regulates Myofibroblast Emergence and Peritubular Capillary Stability in the Early Stages of Kidney Fibrosis

Endothelial Activin Receptor-Like Kinase 1 (ALK1) Regulates Myofibroblast Emergence and Peritubular Capillary Stability in the Early Stages of Kidney Fibrosis

Renal tubulo-interstitial fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the tubular interstitium during chronic kidney disease. The main source of ECM proteins are emerging and proliferating myofibroblasts. The sources of myofibroblasts in the renal tubular...

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Bibliographic Details
Main Authors: Carlos Martínez-Salgado, Fernando Sánchez-Juanes, Francisco J. López-Hernández, José M. Muñoz-Félix
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
ALK1
Angiogenesis
peritubular capillaries
myofibroblasts
fibrosis
chronic kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.843732/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.843732/full

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