Validation and interpretation of IGH and TCR clonality testing by Ion Torrent S5 NGS for diagnosis and disease monitoring in B and T cell cancers

Validation and interpretation of IGH and TCR clonality testing by Ion Torrent S5 NGS for diagnosis and disease monitoring in B and T cell cancers

Cancers of B and T lymphocytes are the most common hematologic malignancies in the US. Molecular assays for assessing clonal rearrangements of the immunoglobulin receptor (IGH) and T-cell receptor (TCR), commonly referred to as B- and T-cell clonality, as well as determination of IGH somatic mutatio...

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Bibliographic Details
Main Authors: Lindsay Lay, Brooke Stroup, Jacqueline E. Payton
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Practical Laboratory Medicine
Subjects:
Leukemia
TCR
Clonality
Next-generation sequencing
Lymphoma
NGS
Online Access:http://www.sciencedirect.com/science/article/pii/S2352551720301542

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http://www.sciencedirect.com/science/article/pii/S2352551720301542

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