Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect

Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect

Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or granules and can therefore only be used for ex...

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Bibliographic Details
Main Authors: Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
nano hydroxyapatite
micro hydroxyapatite
biodistribution
drug delivery
osteosarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1076320/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1076320/full

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