Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function

Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function

Introduction: Triterpenoids and saponins have a broad range of pharmacological activities. Unlike most legumes which contain mainly oleanane-type scaffold, Astragalus membranaceus contains not only oleanane-type but also cycloartane-type saponins, for which the biosynthetic pathways are unknown. Obj...

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Bibliographic Details
Main Authors: Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Advanced Research
Subjects:
Astragalus membranaceus
Oxidosqualene cyclase (OSC)
β-Amyrin
Cycloartenol
Biosynthesis
Conserved motif
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222000765

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